The information below is taken from various studies on Magnesium and its affect on children as well as adults and is available on the internet for public consumption. H2oNero has not conducted studies of their own as yet and are in the process of doing so.

excerpt from Dr Perlmutter

Lately, in the lectures that I have been presenting to medical professionals, I have been emphasizing the virtues of magnesium threonate. Aside from the information I’ve been presenting, I thought it would be good to actually visit and review some of the exciting new information about what clearly appears to be offering up an exciting new area of chemistry related to neuronal function and brain function in general.

Learning is the process by which the brain is able to store new information by forming new connections between neurons in what are called networks. This process is an example of neuroplasticity. This process depends on the actual formation of these connections, as well as the number of connections that are available. We do know that when synapses, the connections that allow one nerve cell to communicate with the next, are diminished, memory impairment ensues. And indeed it is thought that this loss of synapses is an explanation for what is called “age dependent memory decline.”

Synapse formation is dependant upon a variety of factors that have been well studied including insulin, ghrelin, various trophic hormones, and, as we have now learned, the ion magnesium, which enhances the activity of more than 300 enzymes.

It has now been discovered that magnesium is a critical player in the activation of nerve channels that are involved in synaptic plasticity. That means that magnesium is critical for the physiological events that are fundamental to the processes of learning and memory.

As it turns out, one form of magnesium, magnesium threonate, has the unique ability to permeate the brain and enhance the receptors that are involved in this process.

As reported in the journal Neuron researchers demonstrated actual enhancement in the learning abilities, working memory, as well as short as well as long-term memory and even quality of sleep, in laboratory animals, who were given magnesium magnesium threonate.

One of the most aggressively studied forms of magnesium threonate is a patented product called Magteinä, developed by researchers at MIT including a Nobel Prize winner. Their research has  demonstrated actual restoration of function in aging neurons in laboratory animals. Further, it appears that this specific form of magnesium, Magteinä, may in fact be the only form of magnesium that significantly increases the levels of magnesium within the brain. (excerpt from Dr Perlmutter)

https://youtu.be/oZYXBYAHhN8

Magnesium is a critical biological element for human health; it is the second most abundant electrolyte within the cells after potassium and the fourth most common mineral in the human body after calcium, potassium and sodium.

An electrolyte of chief physiological importance, cells die without adequate magnesium. Low levels also adversely affect over 300 enzyme systems involved in protein synthesis, muscle, hormone, bone and nerve function and blood glucose control, along with energy, DNA and RNA production.[1] Magnesium is also required for intracellular homeostasis, the activation of vitamin B1 and the utilisation of other important nutrients, such as calcium, potassium, zinc, iron and vitamin D5.

These are all crucial factors needed in the growth, development and neurological wellbeing of children. Unfortunately, magnesium deficiency is a common and widespread problem. If left untreated, it will inevitably lead to metabolic dysregulation and many physical and mental health concerns.

Magnesium is crucial for healthy mood and bone development in kids

Magnesium is necessary for the conversion of vitamin D into its active form, which in turn supports calcium absorption and metabolism, and parathyroid hormone function required for bone growth and development. With around 52% of the magnesium stores located in the bone and approximately 40% of peak bone mass accumulated by adolescence, the best time to influence bone mass is in the early years; therefore, optimal magnesium levels are especially important for children. Additionally, adult studies show that higher magnesium levels correlate with higher bone mineral density (BMD).

Magnesium is also important for calm moods and relaxation in children. It is a natural N-methyl-D-aspartate (NMDA) antagonist and a gamma-aminobutyric acid (GABA) agonist, both of which have a calming and relaxing effect, as well as facilitating sleep. Therefore, a deficiency in magnesium can increase agitation, anxiety, irritability, hyperexcitability, attention and aggression problems in children. 

Stress, whether physical, or emotional increases the need for magnesium. Additionally, when stressed the body releases magnesium from the cells, increasing its potential for excretion and further creating a deficiency state.

One study showed dietary magnesium intakes are inversely associated with externalising behaviour problems, such as aggression and attention issues, in adolescents. Deficiencies have also been recorded in children with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD).



The reasons for childhood magnesium deficiencies

There is insufficient data on the level of magnesium deficiency specifically in children; however, it is estimated that at least 42% of young adults have an ongoing magnesium deficiency. The main cause of deficiency in humans is inadequate intake but with children the requirements are increased because of constant growth and development. 

Additionally, many factors affect both the intake and absorption of magnesium, and it will be readily excreted from the body if these conditions are not being met. 

Lack of adequate magnesium intake 
Children that are the most prone to magnesium deficiencies are the ‘picky eaters’ and those on low fibre, low vegetable, restricted, highly processed or nonorganic diets and any child with eating or sensory disorders. 

The foods commonly eaten foods by children, such as meat and refined carbohydrates (e.g. white flour in breads, baking and crackers etc.) provide less than 20% of the daily requirement of magnesium, as processing can lower the magnesium content in grains by up to 300-400%.[1] Other foods, such as root vegetables, fruits, oils and fats contribute very little magnesium to the diet. 

Food processing at home, as in the cooking and boiling of vegetables, can also result in significant magnesium losses.

Additionally, the quality of the soil and farming practices are also a factor in obtaining an adequate daily intake of magnesium. Certain modern fertilisation and agricultural techniques have led to soils depleted of minerals, without replenishment. This is evident in Australia with many parts of Victoria and NSW having magnesium deficient pasture soils. Organic meats and vegetables may also be a consideration with some commonly used pesticides in nonorganic foods, including glyphosate, able to chelate minerals, and potentially reduce soil magnesium content.

A lack of mineralised water, due to overall reduced water intake or from only drinking demineralised water, may also contribute to magnesium insufficiency.

Diets high in sugar, salt and soft drinks
Consuming soft drinks, which can be high in phosphoric acid, increases the depletion of magnesium. These drinks may also replace the intake of water, and without adequate hydration the body will excrete more magnesium to retain the salinity of the urine, as it does with sodium. A high salt diet will also increase magnesium excretion.

Soft drinks are often high in sugar too, which is detrimental to both magnesium stores and retention, with data showing that magnesium is depleted in a diet high in sugar. Magnesium is essential for carbohydrate metabolism and both the manufacture and action of insulin (insulin-mediated-glucose-uptake), with magnesium deficiency linked to type 2 diabetes and prediabetes. Both high blood glucose and insulin levels increase urinary magnesium excretion.

Factors that reduce magnesium absorption 
Absorption figures vary, but can be between 25% to 75%, depending on if the diet is magnesium rich or depleted. Adequate absorption requires plenty of magnesium in the diet and nutrients, such as vitamin D, selenium and vitamin B6. Factors that can hinder absorption also include: 

  • a low protein diet (data shows less than 30g/day for adults)
  • a high saturated fat diet
  • vitamin D deficiency, prevalent when consuming a western diet, and a lack of sunlight exposure
  • nutrient deficiencies
  • medications commonly given to children, such as antibiotics, inhaled corticosteroids, antihistamines and antacids.

Other factors that increase magnesium losses
Very active children or those who sweat easily may require extra magnesium, as 10%-15% of the total magnesium excreted from the body is through sweat. Increased losses will also be seen with prolonged diarrhoea, vomiting or excess renal excretion (seen in bowel disease, laxative use and diabetes).

Prolonged, intense stress, worry and anxiety over school, friends, sports, and relationships, especially in the absence of magnesium-rich foods, increases elimination considerably, as do nutrient deficiencies such as selenium.

Signs and symptoms that show kids may need extra magnesium:

  • Twitching muscles, muscle tension, spasms (particularly in small muscles, such as the eye lid), leg cramps or growing pains 
  • Excessive worry, anxiety, irritability and panic attacks 
  • Restlessness and difficulty sleeping
  • Difficulty maintaining attention, hyperexcitability and hyperactivity
  • Teeth grinding
  • Sensitivity to noise
  • Muscular weakness and lethargy
  • Constipation.

Conditions in children that may require magnesium supplementation:

  • Attention deficit disorder (ADD) and ADHD
  • Anxiety and depression
  • Asthma
  • Atopic dermatitis
  • ASD
  • Cystic fibrosis
  • Diabetes
  • General behavioural difficulties, aggression and mood swings
  • Insomnia and sleep disturbances
  • Low gastric acid secretion
  • Muscle cramps/growing pains
  • Migraine headaches
  • Obesity and unfavourable blood lipid profiles
  • Physical performance
  • Pinworm/threadworm or giardia infestations
  • Prehypertension and hypertension
  • Recurrent bacterial and fungal infections
  • Restless leg syndrome
  • Stress
  • Tourette’s syndrome

Adverse effects of magnesium in kids

When ingested within foods, magnesium has no toxicity risk or side effects.[10] With supplementation, the only side effect that may be seen is diarrhoea, which is classed as the first sign of excess intake (above 350mg/day). Reducing the dose or dividing the total daily amounts across the day will lessen this effect and maximise bioavailability. Care may be required for children with renal impairment.

Conclusion

Magnesium deficiency is linked to a range of clinical conditions, because of its crucial role in hundreds of essential biochemical pathways. As it is often difficult to encourage children to eat a wide and varied diet, it is important that all potential risks of deficiency are taken into account, with serious considerations for supplementation of this non-toxic mineral, if required. The half-life of magnesium is 42 days, so correcting deficiencies in children consuming inadequate levels, may require long-term supplementation.

RECOMMENDED DIETARY ALLOWANCES (RDAS) – MAGNESIUM